Journal Articles Tetrahedron Letters Year : 2011

Bromination of 3-substituted benzo[b]thiophenes : access to raloxifen intermediate.

Abstract

A practical route to prepare halogeno-derivatives is described, starting from easily available 3-cyano-benzo[b]thiophene. Main efforts have been devoted to the optimization of the experimental procedures (solvent, bromination) to promote selectivity. Synthetic studies investigate the potential access to an advanced intermediate of Raloxifen.

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Dates and versions

hal-01168536 , version 1 (26-06-2015)

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  • HAL Id : hal-01168536 , version 1

Cite

François Liger, S Pellet-Rostaing, Florence Popowycz, Marc Lemaire. Bromination of 3-substituted benzo[b]thiophenes : access to raloxifen intermediate.. Tetrahedron Letters, 2011, 52 (29), pp.3736-3739. ⟨hal-01168536⟩
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