Reducing the global burden of HTLV-1 infection: An agenda for research and action
Luc Willems
(1)
,
Hideki Hasegawa
(2)
,
Roberto Accolla
(3)
,
Charles Bangham
(4)
,
Ali Bazarbachi
(5)
,
Umberto Bertazzoni
(6)
,
Anna Barbara de Freitas Carneiro-Proietti
(7)
,
Hua Cheng
(8)
,
Luigi Chieco-Bianchi
(9)
,
Vincenzo Ciminale
(9)
,
Jordana Coelho-Dos-Reis
(10)
,
José Esparza
(8)
,
Robert Gallo
(8)
,
Antoine Gessain
(11)
,
Eduardo Gotuzzo
(12)
,
William Hall
(13)
,
Joseph Harford
(14)
,
Olivier Hermine
(15)
,
Steven Jacobson
(16)
,
Beatrice Macchi
(17)
,
Calum Macpherson
(18)
,
Renaud Mahieux
(19)
,
Masao Matsuoka
(20)
,
Edward Murphy
(21)
,
Jean-Marie Peloponese
(22)
,
Viviana Simon
(23)
,
Yutaka Tagaya
(8)
,
Graham Taylor
(4)
,
Toshiki Watanabe
(24)
,
Yoshihisa Yamano
(25)
1
Université de Liège
2 National Institute of Infectious Diseases [Tokyo]
3 Uninsubria - Universitá degli Studi dell’Insubria = University of Insubria [Varese]
4 Imperial College London
5 AUB - American University of Beirut [Beyrouth]
6 UNIVR - Università degli studi di Verona = University of Verona
7 Fundação Hemominas
8 IHV - Institute of Human Virology
9 Unipd - Università degli Studi di Padova = University of Padua
10 Fiocruz Minas - René Rachou Research Center / Instituto René Rachou [Belo Horizonte, Brésil]
11 IP - Institut Pasteur [Paris]
12 IMT AvH - Instituto de Medicina Tropical "Alexander von Humboldt"
13 Centre for Research in Infectious Diseases
14 NCI-NIH - National Cancer Institute [Bethesda]
15 Service d'immuno-hématologie pédiatrique [CHU Necker]
16 NINDS - National Institute of Neurological Disorders and Stroke [Bethesda]
17 Università degli Studi di Roma Tor Vergata [Roma, Italia] = University of Rome Tor Vergata [Rome, Italy] = Université de Rome Tor Vergata [Rome, Italie]
18 St. George's University [Grenada]
19 ENS de Lyon - École normale supérieure de Lyon
20 Kyoto University
21 UC San Francisco - University of California [San Francisco]
22 IRIM - Institut de Recherche en Infectiologie de Montpellier
23 MSSM - Icahn School of Medicine at Mount Sinai [New York]
24 UTokyo - The University of Tokyo
25 St. Marianna University, Kawasaki
2 National Institute of Infectious Diseases [Tokyo]
3 Uninsubria - Universitá degli Studi dell’Insubria = University of Insubria [Varese]
4 Imperial College London
5 AUB - American University of Beirut [Beyrouth]
6 UNIVR - Università degli studi di Verona = University of Verona
7 Fundação Hemominas
8 IHV - Institute of Human Virology
9 Unipd - Università degli Studi di Padova = University of Padua
10 Fiocruz Minas - René Rachou Research Center / Instituto René Rachou [Belo Horizonte, Brésil]
11 IP - Institut Pasteur [Paris]
12 IMT AvH - Instituto de Medicina Tropical "Alexander von Humboldt"
13 Centre for Research in Infectious Diseases
14 NCI-NIH - National Cancer Institute [Bethesda]
15 Service d'immuno-hématologie pédiatrique [CHU Necker]
16 NINDS - National Institute of Neurological Disorders and Stroke [Bethesda]
17 Università degli Studi di Roma Tor Vergata [Roma, Italia] = University of Rome Tor Vergata [Rome, Italy] = Université de Rome Tor Vergata [Rome, Italie]
18 St. George's University [Grenada]
19 ENS de Lyon - École normale supérieure de Lyon
20 Kyoto University
21 UC San Francisco - University of California [San Francisco]
22 IRIM - Institut de Recherche en Infectiologie de Montpellier
23 MSSM - Icahn School of Medicine at Mount Sinai [New York]
24 UTokyo - The University of Tokyo
25 St. Marianna University, Kawasaki
Luc Willems
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- Function : Correspondent author
- PersonId : 1048401
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Ali Bazarbachi
- Function : Author
- PersonId : 757069
- ORCID : 0000-0002-7171-4997
Vincenzo Ciminale
- Function : Author
- PersonId : 914493
Antoine Gessain
- Function : Author
- PersonId : 1175803
- ORCID : 0000-0001-6840-4413
- IdRef : 07692193X
Eduardo Gotuzzo
- Function : Author
- PersonId : 952413
Olivier Hermine
- Function : Author
- PersonId : 1308844
- ORCID : 0000-0003-2574-3874
- IdRef : 069884927
Jean-Marie Peloponese
- Function : Author
- PersonId : 175362
- IdHAL : jean-marie-peloponese
- ORCID : 0000-0002-9677-9703
- IdRef : 061663360
Toshiki Watanabe
- Function : Author
- PersonId : 795179
- ORCID : 0000-0002-1198-3773
Yoshihisa Yamano
- Function : Author
- PersonId : 795180
- ORCID : 0000-0001-7527-0345
Abstract
Even though an estimated 10-20 million people worldwide are infected with the oncogenic retrovirus, human T-lymphotropic virus type 1 (HTLV-1), its epidemiology is poorly understood, and little effort has been made to reduce its prevalence. In response to this situation, the Global Virus Network launched a taskforce in 2014 to develop new methods of prevention and treatment of HTLV-1 infection and promote basic research. HTLV-1 is the etiological agent of two life-threatening diseases, adult T-cell leukemia and HTLV-associated myelopathy/tropical spastic paraparesis, for which no effective therapy is currently available. Although the modes of transmission of HTLV-1 resemble those of the more familiar HIV-1, routine diagnostic methods are generally unavailable to support the prevention of new infections. In the present article, the Taskforce proposes a series of actions to expand epidemiological studies; increase research on mechanisms of HTLV-1 persistence, replication and pathogenesis; discover effective treatments; and develop prophylactic and therapeutic vaccines.