Neutralizing antibodies against SARS-CoV-2 variants following mRNA booster vaccination in adults older than 65 years

Christine Durier; Laetitia Ninove; Maeva Lefebvre; Anne Radenne; Corinne Desaint; Jacques Ropers; Rebecca Bauer; Said Lebbah; Diane Carette; Marie Lachatre; Anne-Sophie Lecompte; Dominique Deplanque; Elisabeth Botelho-Nevers; Anne Conrad; Bertrand Dussol; Zoha Maakaroun-Vermesse; Giovanna Melica; Jean-François Nicolas; Renaud Verdon; Jacques Kiladjian; Paul Loubet; Catherine Schmidt-Mutter; Christian Dualé; Séverine Ansart; Stéphane Priet; Axel Levier; Diana Molino; Louis-Victorien Vieillard; Béatrice Parfait; Jean-Daniel Lelièvre; Eric Tartour; Xavier de Lamballerie; Odile Launay; Gilbert Mchantaf; Berthe-Marie Imbert-Marcille; Samantha Montagne; Bijan Ghaleh-Marzban; Alexandra Traverse-Glehen; Denis Vivien; Bruno Cassinat; Alexandre Evrard; Catherine Metzger; Jean-Marc Lessinger; Michel Billing; Marc Berger; Christophe Leroyer; Eric Tartour; Victor Appay; Frédéric Batteux; Béhazine Combadière; Guy Gorochov; Stéphane Paul; Sylvie van der Werf; Christiane Eberhardt; Claire-Anne Siegrist; Michel Cogné; Isabelle Pellegrin; Marc Eloit; Emmanuelle Netzer; Martine Resch; Marine Saouzanet; Laurence Meyer; Marion Bonneton; Raphaelle Tardieu; Soizic Le Mestre; Solange Jancrey-Laval; Ventzislava Petrov-Sanchez; Eric Rosenthal; Yazdan Yazdanpanah; Daniel Olive; Raphaelle Tardieu; Ventzislava Petrov-Sanchez; Amel Bouakane; Veronique Rieux; Claire Madelaine; Soizic Lemestre; Alpha Diallo; Solange Lancrey-Javal; Laurence Meyer; Emmanuelle Netzer; Marine Saouzanet; Florent Valour; Bertrand Dussol; Giovanna Melica; Gilbert Mchantaf; Michael Hisbergues; Frédérique Bertholon; Vinca Icard; Annachiara de Sandre-Giovannoli; Bijan Ghaleh-Marzban; Victor Appay; Frédéric Batteux; Béhazine Combadière; Guy Gorochov; Stéphane Paul; Sylvie van der Werf; Christiane Eberhardt; Claire-Anne Siegrist; Michel Cogné; Margot Dropy; Fatiha Bouchama; Mehdi Thamri; Saïd Lebbah; Marion Bonneton; Shorheh Azimi; Beatrice Parfait; Victor Appay; Frédéric Batteux; Béhazine Combadière; Guy Gorochov; Stéphane Paul; Sylvie van der Werf; Claire-Anne Siegrist; Michel Cogné; Florent Valour

doi:10.1038/s41598-022-24409-w

Journal Articles Scientific Reports Year : 2022

Neutralizing antibodies against SARS-CoV-2 variants following mRNA booster vaccination in adults older than 65 years

(1) , (2) , (3, 4) , (5) , (6) , , , , , (6) , , (7) , (8) , (9) , (10) , (11) , (12) , , (13) , (14) , (15) , (16) , (17) , (18) , , , (6) , (6) , , , , , (6) , , , , , , , , , , , , , , , , , , , , , , , (19, 20, 21) , , , , , , , (6) , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , (6) , , , , , , , , , , ,

1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21

Christine Durier

Function : Correspondent author
PersonId : 1422047

Connectez-vous pour contacter l'auteur

INSERM SC10 – US19 Essais thérapeutiques et maladies infectieuses

Laetitia Ninove

Function : Author

Unité des Virus Emergents

Maeva Lefebvre

Function : Author

Centre d’Investigation Clinique de Nantes

Centre Hospitalier Universitaire de Nantes = Nantes University Hospital

Anne Radenne

Function : Author

CHU Pitié-Salpêtrière [AP-HP]

Corinne Desaint

Function : Author

CIC Cochin Pasteur

Jacques Ropers

Function : Author

Rebecca Bauer

Function : Author

Said Lebbah

Function : Author

Diane Carette

Function : Author

Marie Lachatre

Function : Author

CIC Cochin Pasteur

Anne-Sophie Lecompte

Function : Author

Dominique Deplanque

Function : Author

Centre d'Investigation Clinique - Innovation Technologique de Lille - CIC 1403 - CIC 9301

Elisabeth Botelho-Nevers

Function : Author
PersonId : 1452409
IdHAL : ebotelhonevers
ORCID : 0000-0003-2773-7750
IdRef : 128018674

Centre d'Investigation Clinique - Epidémiologie Clinique [CHU Saint-Etienne]

Anne Conrad

Function : Author
PersonId : 1275423
ORCID : 0000-0001-6468-2002

Centre International de Recherche en Infectiologie

Bertrand Dussol

Function : Author

Centre d'Investigation Clinique [Hôpital de la Conception - APHM]

Zoha Maakaroun-Vermesse

Function : Author

Centre d’Investigation Clinique [Tours] CIC 1415

Giovanna Melica

Function : Author

Department of Biological Sciences [Boca Raton]

Jean-François Nicolas

Function : Author
PersonId : 937577
ORCID : 0000-0003-4204-803X

Renaud Verdon

Function : Author

Dynamique Microbienne associée aux Infections Urinaires et Respiratoires

Jacques Kiladjian

Function : Author

CIC Saint Louis

Paul Loubet

Function : Author

Virulence Bactérienne et Infections Chroniques

Catherine Schmidt-Mutter

Function : Author

CIC Strasbourg

Christian Dualé

Function : Author
PersonId : 921527
IdHAL : christian-duale

Centre d'Investigation Clinique [CHU Clermont-Ferrand]

Séverine Ansart

Function : Author

CIC Brest

Stéphane Priet

Function : Author

Axel Levier

Function : Author

Diana Molino

Function : Author

CIC Cochin Pasteur

Louis-Victorien Vieillard

Function : Author

CIC Cochin Pasteur

Béatrice Parfait

Function : Author

Jean-Daniel Lelièvre

Function : Author

Eric Tartour

Function : Author

Xavier de Lamballerie

Function : Author

Odile Launay

Function : Author

CIC Cochin Pasteur

Gilbert Mchantaf

Function : Author

Berthe-Marie Imbert-Marcille

Function : Author

Samantha Montagne

Function : Author

Bijan Ghaleh-Marzban

Function : Author

Alexandra Traverse-Glehen

Function : Author

Denis Vivien

Function : Author

Bruno Cassinat

Function : Author

Alexandre Evrard

Function : Author

Catherine Metzger

Function : Author

Jean-Marc Lessinger

Function : Author

Michel Billing

Function : Author

Marc Berger

Function : Author

Christophe Leroyer

Function : Author

Eric Tartour

Function : Author

Victor Appay

Function : Author

Frédéric Batteux

Function : Author

Béhazine Combadière

Function : Author

Guy Gorochov

Function : Author

Stéphane Paul

Function : Author
PersonId : 1047436
ORCID : 0000-0002-8830-4273
IdRef : 070306079

Sylvie van der Werf

Function : Author

Christiane Eberhardt

Function : Author

Claire-Anne Siegrist

Function : Author

Michel Cogné

Function : Author
PersonId : 1089422
IdHAL : michel-cogne

Microenvironment and B-cells: Immunopathology,Cell Differentiation, and Cancer

Etablissement français du sang [Rennes]

Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou]

Isabelle Pellegrin

Function : Author

Marc Eloit

Function : Author

Emmanuelle Netzer

Function : Author

Martine Resch

Function : Author

Marine Saouzanet

Function : Author

Laurence Meyer

Function : Author

Marion Bonneton

Function : Author

CIC Cochin Pasteur

Raphaelle Tardieu

Function : Author

Soizic Le Mestre

Function : Author

Solange Jancrey-Laval

Function : Author

Ventzislava Petrov-Sanchez

Function : Author

Eric Rosenthal

Function : Author

Yazdan Yazdanpanah

Function : Author

Daniel Olive

Function : Author
PersonId : 758587
ORCID : 0000-0003-1299-4113
IdRef : 069162441

Raphaelle Tardieu

Function : Author

Ventzislava Petrov-Sanchez

Function : Author

Amel Bouakane

Function : Author

Veronique Rieux

Function : Author

Claire Madelaine

Function : Author

Soizic Lemestre

Function : Author

Alpha Diallo

Function : Author

Solange Lancrey-Javal

Function : Author

Laurence Meyer

Function : Author

Emmanuelle Netzer

Function : Author

Marine Saouzanet

Function : Author

Florent Valour

Function : Author
PersonId : 941069

Bertrand Dussol

Function : Author

Giovanna Melica

Function : Author

Gilbert Mchantaf

Function : Author

Michael Hisbergues

Function : Author

Frédérique Bertholon

Function : Author

Vinca Icard

Function : Author

Annachiara de Sandre-Giovannoli

Function : Author

Bijan Ghaleh-Marzban

Function : Author

Victor Appay

Function : Author

Frédéric Batteux

Function : Author

Béhazine Combadière

Function : Author

Guy Gorochov

Function : Author

Stéphane Paul

Function : Author

Sylvie van der Werf

Function : Author

Christiane Eberhardt

Function : Author

Claire-Anne Siegrist

Function : Author

Michel Cogné

Function : Author

Margot Dropy

Function : Author

Fatiha Bouchama

Function : Author

Mehdi Thamri

Function : Author

Saïd Lebbah

Function : Author

Marion Bonneton

Function : Author

CIC Cochin Pasteur

Shorheh Azimi

Function : Author

Beatrice Parfait

Function : Author

Victor Appay

Function : Author

Frédéric Batteux

Function : Author

Béhazine Combadière

Function : Author

Guy Gorochov

Function : Author

Stéphane Paul

Function : Author

Sylvie van der Werf

Function : Author

Claire-Anne Siegrist

Function : Author

Michel Cogné

Function : Author

Florent Valour

Function : Author

Abstract

Immune response induced by COVID-19 vaccine booster against delta and omicron variants was assessed in 65 adults (65–84 years old) early aftesr a first booster dose. An increase in SARS-CoV-2 neutralizing antibodies was shown in individuals not previously infected without evidence of an age-related effect, with lower increase in those infected before a single dose of primary vaccination. Of note, humoral response was observed only starting from the 5th day after the boost.

Keywords

Biomarkers Medical research

Domains

Vaccinology

Fichier principal

s41598-022-24409-w.pdf (1.6 Mo)

41598_2022_24409_MOESM1_ESM.pdf (851.01 Ko)

Origin	Publisher files allowed on an open archive

Laurent Jonchère : Connect in order to contact the contributor

https://u-paris.hal.science/hal-04119081

Submitted on : Friday, October 4, 2024-12:17:21 PM

Last modification on : Tuesday, December 17, 2024-12:47:01 PM

Dates and versions

hal-04119081 , version 1 (04-10-2024)

Licence

Attribution

Identifiers

HAL Id : hal-04119081 , version 1
DOI : 10.1038/s41598-022-24409-w
PUBMED : 36437298

Cite

Christine Durier, Laetitia Ninove, Maeva Lefebvre, Anne Radenne, Corinne Desaint, et al.. Neutralizing antibodies against SARS-CoV-2 variants following mRNA booster vaccination in adults older than 65 years. Scientific Reports, 2022, 12 (1), pp.20373. ⟨10.1038/s41598-022-24409-w⟩. ⟨hal-04119081⟩

Export

BibTeX XML-TEI Dublin Core DC Terms EndNote DataCite

Collections

INSERM UNIV-ST-ETIENNE ENS-LYON IRD UNIV-BREST UNIV-RENNES1 CNRS UNIV-AMU UNIV-LYON1 COMUE-NORMANDIE UNIV-MONTPELLIER SITE-ALSACE UNIV-RENNES UNIROUEN UNIV-LILLE UNICAEN CIRI SORBONNE-UNIVERSITE SU-MEDECINE UDL UR1-BIO-SA DYNAMICURE CIC1417 MOBIDIC

148 View

22 Download

Neutralizing antibodies against SARS-CoV-2 variants following mRNA booster vaccination in adults older than 65 years

Abstract

Keywords

Domains

Dates and versions

Licence

Identifiers

Cite

Export

Collections

Altmetric

Share