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European research laboratory for rheumatoid arthritis - GenHotel is a research unit of University of Evry since 1999 on the Genopole campus. For nearly 20 years, our lab has focused on the aetiology of a complex disease, rheumatoid arthritis (RA). After a period consisted of 'classical' genetic analyses through linkage and association studies, results, and particularly GWAS one, lead us to develop alternative approaches. Instead of considering common genomic variants, we decided to focus on rare and specific ones, to identify biomarkers in RA and its phenotypes. In this direction, we developed a global approach to the disease by mapping all the connections. Based on these approaches, our research activity is divided into two main axis: Characterization of new RA genomic variants and Computational systems biology approaches for the construction of graphical and dynamical models of disease mechanisms to study their complex dynamic behavior. Results of the first axis feed the second project, contributing to the development of a pipeline for identifying new lines in RA drug design.

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African Continental Ancestry Group Complex genetic disease Genetics Systems biology Reproducibility Receptors Antigen Presentation Metabolic reprogramming Rheumatoid Arthritis Patient Genetic Predisposition to Disease Rheumatoid arthritis HLA-DR Antigens European Continental Ancestry Group RHEUMATOID ARTHRITIS Adolescent Age of Onset Gene Frequency Rheumatoid Factor HLA-DRB1 Chains Antigens Humans Tunisia Algerian population Young Adult Analysis Europe Antirheumatic Agents PTPN22 gene Anti-citrullinated protein antibodies Biocuration Databases Biologie des systèmes Logical modelling Shared Epitope Environment Rheumatoid Annotation standards Disease maps ABCB1 Autoimmunity Risk Factors Cohort Studies Human genomics Computational biology Transcriptome Epitopes ATP Binding Cassette Transporter ASSOCIATION STUDY APOPTOSIS Adult Single Nucleotide Génétique Female Animals Ankylosing Antibodies Network inference Association study Polyarthrite rhumatoïde Autoantibodies Autoantibody Production In silico simulations Alleles Case-Control Studies Genotype Autoimmune thyroid diseases Phenotype Protein Tyrosine Phosphatase Family Computational systems biology Middle Aged HLA-DRB1 Biological pathway Age Factors Binding Sites Ankylosing spondylitis 80 and over Aged Hybrid modeling Male Rare variants Genetic Association Studies France Haplotypes Odds Ratio Rheumatoid Arthritis Arthritis Genetic Computational modeling Algeria Anti-Idiotypic Family Health Genetic Linkage Polymorphism Autoimmune Diseases Autoimmune thyroid disease POLYMORPHISM Biologie computationnelle des systèmes Non-Receptor Type 22 Linkage Disequilibrium

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