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EUROPEAN RESEARCH LABORATORY FOR RHEUMATOID ARTHRITIS – GENHOTEL

European research laboratory for rheumatoid arthritis - GenHotel is a research unit of University of Evry since 1999 on the Genopole campus. For nearly 20 years, our lab has focused on the aetiology of a complex disease, rheumatoid arthritis (RA). After a period consisted of 'classical' genetic analyses through linkage and association studies, results, and particularly GWAS one, lead us to develop alternative approaches. Instead of considering common genomic variants, we decided to focus on rare and specific ones, to identify biomarkers in RA and its phenotypes. In this direction, we developed a global approach to the disease by mapping all the connections. Based on these approaches, our research activity is divided into two main axis: Characterization of new RA genomic variants and Computational systems biology approaches for the construction of graphical and dynamical models of disease mechanisms to study their complex dynamic behavior. Results of the first axis feed the second project, contributing to the development of a pipeline for identifying new lines in RA drug design.

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Genetic Association Studies Disease maps Polymorphism Metabolic reprogramming Algerian population Shared Epitope Polyarthrite rhumatoïde Analysis Rare variants Humans Alleles HLA-DRB1 Chains HLA-DR Antigens Arthritis Rheumatoid Arthritis Autoimmune Diseases Linkage Disequilibrium Ankylosing Gene Frequency Family Biological pathway PTPN22 gene Biologie des systèmes Genetic Linkage Genetics Ankylosing spondylitis European Continental Ancestry Group 80 and over Adolescent Rheumatoid Risk Factors ABCB1 Adult Autoantibody Production Autoimmune thyroid disease ATP Binding Cassette Transporter Age Factors Antigens Annotation standards Middle Aged Biocuration Rheumatoid Arthritis Patient Binding Sites Antirheumatic Agents Hybrid modeling Phenotype Computational modeling APOPTOSIS Young Adult Complex genetic disease Genetic Predisposition to Disease Animals Algeria Receptors Protein Tyrosine Phosphatase Environment Aged Odds Ratio Tunisia Non-Receptor Type 22 Biologie computationnelle des systèmes France Autoimmune thyroid diseases Association study Autoimmunity RHEUMATOID ARTHRITIS African Continental Ancestry Group Antibodies Cohort Studies Computational systems biology In silico simulations Network inference Reproducibility Computational biology Genetic ASSOCIATION STUDY Anti-citrullinated protein antibodies Single Nucleotide Female POLYMORPHISM Rheumatoid Factor Transcriptome Antigen Presentation Family Health Age of Onset Male Europe Systems biology HLA-DRB1 Genotype Logical modelling Anti-Idiotypic Autoantibodies Case-Control Studies Epitopes Haplotypes Human genomics Génétique Rheumatoid arthritis Databases

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